The O'Reilly series of "in a nutshell" books are reliably useful. I've had books from this series on my shelf for a very long time; I couldn't program sed and awk without the book.So when I set out to teach myself Python during my end of year vacation, I figured I'd need this reference.
Can't really say I've read it - more appropriate to say that in the course of the programs I've been writing to learn Python, I've paged through most of this book. It isn't the sort of thing I can read cover to cover. Unlike the Python Phrasebook which I highly recommend (see separate entry).